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11.
Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. 总被引:47,自引:0,他引:47
H J Jacob K Lindpaintner S E Lincoln K Kusumi R K Bunker Y P Mao D Ganten V J Dzau E S Lander 《Cell》1991,67(1):213-224
The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-characterized model for primary hypertension in humans. High blood pressure in SHRSP shows polygenic inheritance, but none of the loci responsible have previously been identified. To locate genes controlling this quantitative trait, we mapped a large collection of DNA polymorphisms in a cross between SHRSP and the normotensive WKY strain. Here we report strong genetic evidence that a gene, Bp1, having a major effect on blood pressure maps to rat chromosome 10 with a LOD score of 5.10 and is closely linked to the rat gene encoding angiotensin-converting enzyme (ACE), an enzyme that plays a major role in blood pressure homeostasis and is an important target of anti-hypertensive drugs. We also find significant, albeit weaker, linkage to a locus, Bp2, on chromosome 18. We discuss the implications of genetic dissection of quantitative disease-related phenotypes in mammals. 相似文献
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S Y Yan Z R Mao H Y Yang M A Tu S H Li G P Huang G S Li L Guo G Q Jin R F He 《The International journal of developmental biology》1991,35(4):429-435
The nucleus of a blastula cell from Tilapia (Oreochromis nilotica, family Cichlidae, order Perciformes) was transplanted into an enucleated egg of Loach (Paramisgurnus dabryanus, family Cobitidae, order Cypriniformes). From among 3747 nucleo-cytoplasmic hybrid (NCH) eggs two NCH larval fish (0.05%) were obtained; one died on the 6th day and the other died on the 12th day after the operation. Morphological examinations showed that both NCH larval fish had developed normally with an opened mouth except they could not take food after complete utilization of their egg yolk on the 5th day of development. The possible mechanisms for obtaining such inter-order NCH larval fish are discussed. This is the first report indicating that inter-order NCH larval fish can be obtained in spite of their evolutionary divergence. 相似文献
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子宫颈糜烂病毒病因的探讨 总被引:17,自引:0,他引:17
491份宫颈拭子病毒分离结果表明:糜烂宫颈单纯疱疹病毒(HSV)分离阳性率(30.8%)是正常宫颈(2.6%)的11.8倍,用人干扰素治疗一个疗程后,病毒分离率下降至疗前的1/4.36例糜烂宫颈活体组织DNA分子杂交表明,乳头瘤病毒16型(HPV-16)阳性者占52.8和,HPV-18占17.9%,HPV-6B占28.1%,HPV-11占7.7%,251例宫颈糜烂患者经人(?)D型基因工程干扰素双盲对比治疗后,总有效率达93.8%,显效率达60%,分析临床疗效与HSV分离率的变化表明,临床有效病例中有35%(49/140)在治疗后病毒阴转,有57%在疗前疗后均未分离出HSV,有5%在疗前疗后保持阳性不变,有2.9%疗前阴性,疗后阳性,上述结果表明,HSV和HPV与慢性宫颈炎有一定关系。 相似文献
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CAM植物按其对环境的反应可分为两种类型:即专一CAM植物和兼性CAM植物。前者不易受外界环境的变化而改变其CAM性质;后者的光合型可随季节和水分胁迫等而发生变化,也可因人工诱导作用而使其由C_3型转变为CAM型。 相似文献
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我国银杉自1955年发现以来,陆续发现了它的新分布,至今已知在四省、区7个分布区的30多个分布点上,自然生长着银杉3200余株。它们是:广西花坪林区(越城岭南部)6个点有银杉1040抹,其中高5米以上的68株,1~5米的49株,1米以下的923株,最高21.1米,最大胸径83厘米;广西大瑶山4个点有银杉143株,其中高10米以上的94株,1~3米的3株,1米以下的46株,最高30米,最大胸径79.2厘米;湖南罗汉洞(越城岭北部)2个点有银杉58株,5米以上的有45株,最高18米,最大胸径43厘米;湖南罗霄山脉八面山有银杉707株,高1米以上的334株,最高24米,最大胸径46厘米;四川南川金佛山(大娄山东段北部)6个点有银杉527株,其中成年树400余株,最高17米,最大胸径50厘米;百枝山有银杉52株,最高8米,最大胸径27厘米;贵州道真沙河林区(大娄山东段南部)3处12个点有银杉729株,其中高5米以上的105株,2~5米的209株,1~2米的111株,1米以下的304株,最高18.8米,最大胸径48厘米;贵州桐梓白菁有银杉10株,高4~5米的2株,1~3米的6株,1米以下的2株。 银杉分布区范围自北纬24°5′~29°13′14″,东经107°10′~113°40′。其垂直分布自海拔940~1840米,金佛山银杉分布最高,为1600~1840米;罗汉洞银杉分布最低,为940~1060米。分布区内,年均温8.2°~17℃,绝对最低温 相似文献
20.
Shu-Yu Yu Bao-Lin Mao Ping Xiao Wei-Ping Yu Ying-Long Wang Chang-Zhi Huang Wang-Qiu Chen Xiang-Zhan Xuan 《Biological trace element research》1990,24(2-3):105-108
This pilot study evaluated the feasibility and effectiveness of conducting a double-blind clinical trial for the prevention of lung cancer with selenium (Se) in Yunnan Tin Corporation, the People's Republic of China, where the incidence rates of lung cancer are extraordinarily high among the miners. Forty healthy miners were randomized to either 300 μg of Se in high Se malt cakes or an identical placebo of malt cakes daily for one year. Subjects consumed their usual daily diet. The low Se concentrations in plasma (0.05±0.008 μg/mL) and hair (0.442±0.085 μg/g) reflected their low dietary Se intake in the control subjects. In Se-supplemented group, the Se status was increased by 178% for serum and 194.8% for hair. The serum GSHpx activity was increased by 155.7%, whereas the lipid peroxide level was reduced by 74.5% compared to the placebo. The results of UDS assay indicated that the lymphocyte DNA damage induced by ultraviolet irradiation and carcinogen 3,4-benzpyrene could be protected by Se supplementation. Se-supplementation did not affect the liver function test (SGPT), as well as the concentrations of hemoglobin, albumin, and cholesterol. Thus, daily intake of 300 μg Se in form of Se-malt as a chemopreventive measure is safe and effective to humans with low Se status. 相似文献